Dr. Gerald Pier Presents Preclinical Data at ASM Microbe, June 10th, 2022, showing “Vaccination Against The Broadly-Expressed Microbial Antigen PNAG Prevents Cognitive Decline In The APP-PS1 Mouse Model Of Alzheimer’s Disease”.
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Poly-β-(1→6)- N-acetyl-D-glucosamine mediates surface attachment, biofilm formation, and biocide resistance in Cutibacterium acnes
Jeffrey B. Kaplan 1,2*, Colette Cywes-Bentley 3, Gerald B. Pier 3 Nandadeva Yakandawala 4, Miloslav Sailer 4, Marc S. Edwards 4 , and Khalaf Kridin 2
Experimental Urethral Infection with Neisseria gonorrhoeae
Andreea Waltmann, Joseph A. Duncan, Gerald B. Pier, Colette Cywes-Bentley, Myron S. Cohen, and Marcia M. Hobbs
Bacterial Resistance to Antimicrobial Agents.
Varela MF, Stephen J, Lekshmi M, Ojha M, Wenzel N, Sanford LM, Hernandez AJ, Parvathi A, 3 and Kumar SH.
Vaccines for multidrug resistant Gram negative bacteria: lessons from the past for guiding future success.
Lopez-Siles,M, Corral-Lugo A and McConnell MJ.
Biggest Threats and Data. 2019 Antimicrobial Resistance Threats Report.
Center for Disease Control and Prevention
Antibody recognition of bacterial surfaces and extracellular polysaccharides
Caroline Soliman, Gerald B Pier, Paul A Ramsland
Immunization against poly-N-acetylglucosamine reduces neutrophil activation and GVHD while sparing microbial diversity.
Hülsdünker J, Thomas OS, Haring E, Unger S, Gonzalo Núñez N, Tugues S, Gao Z, Duquesne S, Cywes-Bentley C, Oyardi O, Kirschnek S, Schmitt-Graeff A, Pabst O, Koenecke C, Duyster J, Apostolova P, Blaser MJ, Becher B, Pier GB, Häcker G, Zeiser R.
Antibody to Poly-N-acetyl glucosamine provides protection against intracellular pathogens: Mechanism of action and validation in horse foals challenged with Rhodococcus equi
Colette Cywes-Bentley, Joana N. Rocha, Angela I. Bordin, Mariana Vinacur, Safia Rehman ,Tanweer S. Zaidi, Mark Meyer, Sarah Anthony, McKenzie Lambert, Daniel R. Vlock, Steeve Giguère, Noah D. Cohen, Gerald B. Pier
In vitro evaluation of complement deposition and opsonophagocytic killing of Rhodococcus equi mediated by poly-N-acetyl glucosamine hyperimmune plasma compared to commercial plasma products.
Folmar CN, Cywes-Bentley C, Bordin AI, Rocha JN, Bray JM, Kahn SK, Schuckert AE, Pier GB, Cohen ND.
Structural basis for antibody targeting of the broadly expressed microbial polysaccharide poly-N-acetylglucosamine.
Soliman C, Walduck AK, Yuriev E, Richards JS, Cywes-Bentley C, Pier GB, Ramsland PA.
WHO publishes list of bacteria for which new antibiotics are urgently needed
World Health Organization
Extended-spectrum antibodies protective against carbapenemase-producing Enterobacteriaceae.
Skurnik D, Roux D, Pons S, Guillard T, Lu X, Cywes-Bentley C, Pier GB.
Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens
Cywes-Bentley C, Skurnik D, Zaidi T, Roux D, Deoliveira RB, Garrett WS, Lu X, O'Malley J, Kinzel K, Zaidi T, Rey A, Perrin C, Fichorova RN, Kayatani AK, Maira-Litràn T, Gening ML, Tsvetkov YE, Nifantiev NE, Bakaletz LO, Pelton SI, Golenbock DT, Pier