Alopexx announced today that sanofi-aventis exercises option to acquire exclusive and worldwide rights to Alopexx Pharmaceuticals’ novel human monoclonal antibody targeting infectious diseases

February, 2012

– Novel antibody targeted against methicillin-resistant S. aureus ( MRSA ) and other serious infectious diseases-

Cambridge, MA , October 27, 2010 – sanofi-aventis (EURONEXT: SAN and NYSE: SNY) has recently elected to exercise its option to acquire an exclusive and worldwide license of Alopexx’s F598 antibody following review of the results generated during its collaboration period with Alopexx Pharmaceuticals, LLC . F598 a first-in-class human monoclonal antibody for the prevention and treatment of S. aureus, S. epidermidis, E. coli, Y. pestis (the bacterium that causes plague) and other serious infections. Clinical trials with the antibody were initiated last Spring.

“Our collaboration with sanofi-aventis has been extremely productive and successful”, said Daniel Vlock, MD, CEO of Alopexx Pharmaceuticals. “The support of sanofi-aventis’ development teams was instrumental in permitting us to rapidly begin clinical trials with our antibody. With sanofi-aventis now taking the lead role developing Alopexx’s antibody we have great confidence in the ultimate success of this program.”

Under the collaboration and research agreement, Alopexx initiated a Phase I trial in May, 2010. In that trial administration of F598 was well tolerated and no serious side effects were noted. The initial results of that trial along with other research activities were key in sanofi-aventis’ decision to exercise its option for an exclusive worldwide license. Alopexx is eligible for development, regulatory and commercial milestone payments which could reach $375 million in total, as well as royalties on sales of products commercialized under the license and collaboration.

About Alopexx’s novel human antibody

The therapy is a human monoclonal antibody that has the potential to serve as an alternative to antibiotics in the fight against MRSA (methicillin-resistant S. aureus) and other infections. Unlike antibiotics, monoclonal antibodies are not expected to lead to the development of bacterial resistance to the therapy. The target of the antibody is a carbohydrate on the bacterial capsule known as PNAG. PNAG has been found to be a critical factor in the virulence and immune response to staphylococcal infections. S. aureus strains that cannot produce PNAG have a significantly reduced ability to cause infections. The antibody is directed against PNAG and works by inducing killing by the patient’s own white blood cells. The antibody was initially developed by Drs. Gerald Pier and Casie Kelly-Quintos at the Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School in collaboration with Drs. Lisa Cavacini and Marshall Posner at the Human Monoclonal Antibody Laboratory at Beth Israel Deaconess Medical Center, Harvard Medical School.

About hospital-acquired and resistant infections

It is estimated that there were approximately 2.9 million cases of hospital-acquired infections in the US in 2005. 1.2 million of those were due to Gram-positive organisms, such as staphylococcus. That number is expected to increase to 1.9 million by 2010. Over the same time period infections resistant to multiple anti-bacterials are expected to almost double from over 600,000 to close to 1.2 million.

About Alopexx Pharmaceuticals (LLC)

Alopexx Pharmaceuticals ( was co-founded by Gerald Pier, PhD Professor of Medicine (Microbiology and Molecular Genetics) at Brigham and Women’s Hospital and Harvard Medical School and Daniel Vlock, MD. Its aim is to develop and explore the use of novel therapies for the treatment and prevention of MRSA and other serious infections. For more information contact Daniel Vlock, MD at

About sanofi-aventis

Sanofi-aventis, a leading global pharmaceutical company, discovers, develops and distributes therapeutic solutions to improve the lives of everyone. Sanofi-aventis is listed in Paris (EURONEXT: SAN) and in New York (NYSE: SNY).

Forward Looking Statements

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