Janus Biotherapeutics is developing a novel, orally available TLR 7/8/9 receptor antagonist for the treatment of autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis, Sjogren’s syndrome and psoriasis. There is widespread scientific consensus that TLRs or Toll-like receptors play an important role in the immune system and in aberrant immune responses. By blocking these unwanted immune responses, a TLR 7/8/9 antagonist offers the promise of providing a novel therapy for a wide range of autoimmune diseases.
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